Illustrative image only. Actual pharmacy packaging may vary. The white applicator shown is for illustration only and does not come with the product.
Estrogen + Peptide Renewal CreamRx
A physician-prescribed compounded cream that combines topical estriol — a form of estrogen — with niacinamide and GHK-Cu (copper peptide). Formulated with mature and menopausal skin in mind, it aims to support firmness, tone and a comfortable barrier. Estriol-containing formulas are prescribed only when appropriate after your provider reviews your history; prepared by a licensed U.S. pharmacy and delivered to your door.
- Topical estriol paired with niacinamide and the copper peptide GHK-Cu
- Formulated for mature and menopausal skin
- Prescribed only when appropriate — reviewed by a licensed provider
No membership fee · same price at every dose
From the Harmon family — trusted in health & wellness for over 50 years.
How the formula works
Topical estriol is a form of estrogen studied for its effects on skin; paired with niacinamide (which supports the barrier and tone) and GHK-Cu (which supports collagen), the formula targets the firmness and comfort changes that can come with mature and menopausal skin.
Support cell turnover
Prescription actives like tretinoin speed skin-cell turnover — helping unclog pores, refine rough texture and keep breakouts from forming.
Support collagen & firmness
With consistent nightly use, retinoids and copper peptides (GHK-Cu) support the skin’s own collagen to help soften fine lines and firm the skin over time.
Calm, even & hydrate
Supporting ingredients — niacinamide, hyaluronic acid and, in select formulas, topical estriol — help calm redness, even tone and keep the barrier comfortable.
One price covers everything
Provider care
Online visit, prescription & follow-ups with a licensed clinician.
Your formula
Prescribed and compounded by a licensed U.S. pharmacy.
Free shipping
Delivered free and discreetly to your door.
Unlimited messaging
Reach your care team anytime with questions.
Questions, answered
You'll see your exact price at checkout before you pay. One transparent price covers your online visit, your prescription formula from a licensed U.S. pharmacy, and free, discreet shipping. No insurance or membership required.
Prescription skincare takes time. Most people notice smoother texture and clearer skin by 6–12 weeks, with fine lines and tone continuing to improve over 3–6 months of consistent nightly use. An early "purge" — a temporary uptick in breakouts or flaking — can be normal as skin adjusts.
Yes. A U.S.-licensed provider reviews your online visit — including photos of your skin — and prescribes a formula only when it is appropriate for you. No in-person appointment needed.
Tretinoin, GHK-Cu, niacinamide, hyaluronic acid and estriol are well-studied skincare ingredients. The multi-ingredient formulas are compounded by licensed U.S. pharmacies and, as compounded products, are not FDA-approved. Your provider reviews what is appropriate for you.
No. Tretinoin and other retinoids, and estriol-containing formulas, should not be used during pregnancy or while breastfeeding. Tell your provider if you are pregnant, may become pregnant, or are breastfeeding and they will recommend appropriate alternatives.
More prescription skincare
Tretinoin Renewal Cream
The gold-standard prescription retinoid — smooths fine lines, refines texture and keeps breakouts from forming, with strength tailored to your skin.
RX SkinCare
See the full prescription skincare lineup — retinoids, copper peptides and estriol formulas.
Real physicians. Certified pharmacies.
Care from licensed U.S. physicians
- Every plan is reviewed and prescribed by a U.S.-licensed physician — never a bot or an algorithm.
- Your provider reviews your full medical history and prescribes only when treatment is appropriate for you.
- The same care team stays with you — adjusting your dose and answering questions at every step.
Only 503A-certified pharmacies
We dispense only through U.S. state-licensed 503A compounding pharmacies — the highest-certified partners we work with, following USP compounding standards.
- U.S. state-licensed 503A compounding pharmacies
- Tested for purity and potency
- Shipped free and discreetly to your door
Important safety information
Prescription skincare requires an online consultation with a licensed provider who determines whether treatment is appropriate for you. Tretinoin and other retinoids, and estriol-containing formulas, must not be used during pregnancy or while breastfeeding; retinoids increase sensitivity to the sun — daily broad-spectrum SPF is essential. Expect some dryness, flaking, redness or a temporary "purge" when starting; introduce your formula gradually as directed. Estriol is a form of estrogen used topically in select compounded formulas; tell your provider about any personal or family history of hormone-sensitive conditions. Compounded medications are not FDA-approved. This page is general information, not medical advice; individual results vary.