Photo is illustrative. Your medication’s packaging, form and appearance may differ depending on the prescribing pharmacy and your prescribed dose.
Estriol + Estradiol GelRx
A physician-prescribed topical gel combining estriol and estradiol — a Bi-Est blend applied to the skin once daily to help with menopausal symptoms like hot flashes, night sweats and mood changes, without a pill or patch. Prescribed by a licensed U.S. provider and delivered to your door.
- Estriol + estradiol (Bi-Est) for menopausal symptom relief
- Applied to the skin daily — no pill or patch
- Physician-prescribed — no insurance required
No membership fee · same price at every dose
From the Harmon family — trusted in health & wellness for over 50 years.
How topical estrogen helps
Applied to the skin, a Bi-Est blend of estriol and estradiol is absorbed to help replace declining estrogen — easing hot flashes, night sweats and other menopausal symptoms, without a pill or patch. When you have a uterus, estrogen is paired with progesterone; your provider will confirm your plan.
Ease hot flashes
Replacing estrogen helps calm hot flashes and night sweats.
Mood & sleep
Can help with the mood changes and disrupted sleep of menopause.
Needle- and pill-free
A daily gel absorbed through the skin — no tablet or patch.
One price covers everything
Provider care
Online visit, prescription & follow-ups with a licensed clinician.
Your medication
Prescribed and dispensed by a licensed U.S. pharmacy.
Free shipping
Delivered free and discreetly to your door.
Unlimited messaging
Reach your care team anytime with questions.
Questions, answered
You'll see your exact price at checkout before you pay — one transparent price covers your online visit, your medication from a licensed U.S. pharmacy, and free, discreet shipping. No insurance or membership required.
Bi-Est is a compounded blend of two estrogens — estradiol and estriol. Applied as a topical gel, it offers a needle- and pill-free way to deliver estrogen. It is not FDA-approved as a compounded product.
If you have a uterus, estrogen is generally prescribed with progesterone to protect the uterine lining. Your provider will review your history and confirm your plan.
More menopause & HRT care
Estradiol
Body-identical estradiol to ease hot flashes, night sweats and other menopause symptoms — as a daily tablet or a twice-weekly patch.
Menopause & HRT
See the full hormone-therapy lineup — estrogen, progesterone and combination options.
Real physicians. Certified pharmacies.
Care from licensed U.S. physicians
- Every plan is reviewed and prescribed by a U.S.-licensed physician — never a bot or an algorithm.
- Your provider reviews your full medical history and prescribes only when treatment is appropriate for you.
- The same care team stays with you — adjusting your dose and answering questions at every step.
Only 503A-certified pharmacies
We dispense only through U.S. state-licensed 503A compounding pharmacies — the highest-certified partners we work with, following USP compounding standards.
- U.S. state-licensed 503A compounding pharmacies
- Tested for purity and potency
- Shipped free and discreetly to your door
Results, or your money back.
Follow your provider's plan for 90 days. If you don't see progress, we'll refund your program — and you only ever pay if a provider prescribes treatment.
Refund covers the Harmon program fee for your first 90 days when the prescribed plan is followed; already-shipped compounded medication cannot be returned. Full terms provided at checkout.
Important safety information
Prescription hormone therapy requires an online consultation with a licensed provider who determines whether treatment is appropriate for you. Hormone therapy is not suitable for everyone and may carry risks and side effects; your provider will review your history, including any personal or family history of hormone-sensitive conditions. Compounded medications are not FDA-approved. This page is general information, not medical advice; individual results vary.