Photo is illustrative. Your medication’s packaging, form and appearance may differ depending on the prescribing pharmacy and your prescribed dose.
Bi-Est + ProgesteroneRx
A physician-prescribed compounded topical cream combining Bi-Est — a 50/50 blend of estradiol and estriol — with progesterone in one daily application. A complete, provider-tailored menopause regimen, prescribed by a licensed U.S. provider and delivered to your door.
- Bi-Est (estradiol + estriol) paired with progesterone in one cream
- A daily topical cream, compounded and dosed to you by a licensed U.S. pharmacy
- Physician-prescribed — no insurance required
No membership fee · same price at every dose
From the Harmon family — trusted in health & wellness for over 50 years.
How Bi-Est + Progesterone helps
Bi-Est combines two estrogens — estradiol and estriol — for symptom relief, paired with progesterone, in a single compounded cream tailored to you and applied daily.
Broad relief
Bi-Est targets hot flashes, night sweats and other menopause symptoms.
Balanced by design
Progesterone is included alongside estrogen in one provider-tailored regimen.
One daily cream
Compounded together and dosed to you — one regimen, one application.
One price covers everything
Provider care
Online visit, prescription & follow-ups with a licensed clinician.
Your medication
Prescribed and dispensed by a licensed U.S. pharmacy.
Free shipping
Delivered free and discreetly to your door.
Unlimited messaging
Reach your care team anytime with questions.
Questions, answered
You'll see your exact price at checkout before you pay — one transparent price covers your online visit, your compounded medication from a licensed U.S. pharmacy, and free, discreet shipping. No insurance or membership required.
Bi-Est is a compounded blend of two estrogens — estradiol and estriol. Combining it with progesterone in one plan gives a complete, provider-tailored approach to menopause symptoms.
Compounded hormone therapy lets a provider tailor your formulation. It is not FDA-approved, and your provider will review your history to determine whether it is appropriate for you.
More menopause & HRT care
Estradiol
Body-identical estradiol to ease hot flashes, night sweats and other menopause symptoms — as a daily tablet or a twice-weekly patch.
Menopause & HRT
See the full hormone-therapy lineup — estrogen, progesterone and combination options.
Real physicians. Certified pharmacies.
Care from licensed U.S. physicians
- Every plan is reviewed and prescribed by a U.S.-licensed physician — never a bot or an algorithm.
- Your provider reviews your full medical history and prescribes only when treatment is appropriate for you.
- The same care team stays with you — adjusting your dose and answering questions at every step.
Only 503A-certified pharmacies
We dispense only through U.S. state-licensed 503A compounding pharmacies — the highest-certified partners we work with, following USP compounding standards.
- U.S. state-licensed 503A compounding pharmacies
- Tested for purity and potency
- Shipped free and discreetly to your door
Results, or your money back.
Follow your provider's plan for 90 days. If you don't see progress, we'll refund your program — and you only ever pay if a provider prescribes treatment.
Refund covers the Harmon program fee for your first 90 days when the prescribed plan is followed; already-shipped compounded medication cannot be returned. Full terms provided at checkout.
Important safety information
Prescription hormone therapy requires an online consultation with a licensed provider who determines whether treatment is appropriate for you. Hormone therapy is not suitable for everyone and may carry risks and side effects; your provider will review your history, including any personal or family history of hormone-sensitive conditions. Compounded medications are not FDA-approved. This page is general information, not medical advice; individual results vary.